A filler substance is a material that is injected under the skin to increase the fullness of one’s skin and decrease the appearance of wrinkles.

RESTYLANE/PERLANE®

What Are Restylane and Perlane?
The Restylane family of products includes Restylane and Perlane. Both are cosmetic dermal fillers that replace lost volume and restore youthful contours to the skin to smooth away moderate to sever facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds).

How Do I Choose Between Restylane and Perlane?
You don’t have to. In clinical trials, Restylane and Perlane were used in the same patients. The hyaluronic acid in both products is made by the same biotechnical process. The
difference is in the gel particle size. Perlane gel particles are larger and designed for deeper injection than Restylane. Your doctor will decide which product is right for you.

How Long Do Restylane Products Last?
Restylane products are proven to deliver long-lasting results. Restylane lasts about six months. Perlane maintains its effects for at least six month, in a majority of patients. Some Perlane patients maintained results for up to nine months in clinical trials. The products’ patented stabilization technology helps maintain the cosmetic effect for those time periods.

Are Restylane and Perlane FDA Approved?
Yes. They are approved by the FDA for the treatment of moderate to severe facial wrinkles and folds, like the ones from your nose to the corners of your mouth. Ask your physician whether treatment is right for you.

What Is The History Of Restylane?
Restylane has been used in over 1.4 million treatments in the U.S. and is available in more than 70 countries. It is the most-studied cosmetic dermal filler in the world with dozens of publications in medical literature. Clinical studies showed no significant differences in the safety of Restylane and Perlane.

What Should Patients Do Prior To Treatment?
Restylane and Perlane require no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal anti-inflammatory medications, St. John’s Wort, or high doses of Vitamin E supplements prior to treatment, because these may increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, discuss this with your doctor, who may prescribe a medication o minimize recurrence.

Do Restylane and Perlane Require An Allergy Test?
No. Restylane and Perlane do not require an allergy test and can be administered immediately-no waiting is required.

How Are Restylane Products Different Than Other Hyaluronic Acid-based Products?
Restylane and Perlane contain no animal proteins. This limits any risk or animal-based disease transmission or allergic reaction. You should not use Restylane or Perlane if you have allergies to microorganisms known as gram-positive bacteria.

How Are Restylane Products Administered?
Restylane and Perlane are administered by injection to the treatment site. Before treatment talk to your doctor about pain management.

Do The Injections Hurt?
Restylane products are injected directly into the skin in small amounts by an ultra fine needle. As with all injections, some patients may experience discomfort. To increase your
comfort, your doctor will assess your need for pain management and determine what technique is right for you.

How Much Do Treatments Cost?
A Restylane or Perlane procedure is customized to your specific needs, so the cost will vary. In general, the cost is comparable to the cost of similar procedures. Ask your doctor to give a cost estimate based on your particular needs.

How Often Should I Schedule An Appointment?
How long the aesthetic correction lasts is very individual. Talk to your doctor about the benefits of scheduling a follow-up appointment in about six months.

What Are Restylane And Perlane Products Made Of?
Restylane was the first cosmetic dermal filler made from hyaluronic acid that has been modified slightly to last longer than the body’s hyaluronic acid. In the human body natural hyaluronic acid provides volume and fullness to the skin.

Is Any Of The Material Left In The Skin After It Has Dissolved?
No. Over time Restylane and Perlane products are broken down and eliminated by the body-unlike permanent fillers.

Which Dermal Filler Is The Market Leader?
Restylane is the number one selling dermal filler in the U.S. and worldwide.

How Do Restylane And Perlane Products Differ From Botox Cosmetic?
Botox Cosmetic and Restylane are used to correct wrinkles in different ways. Restylane products are cosmetic fillers injected into the skin, adding volume to smooth wrinkles
such as the lines from your nose to the corners of your mouth (nasolabial folds). In contrast, Botox relaxes the muscles that cause frown lines between your eye brows.

Important Safety Considerations of Restylane:
Restylane restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising and bleeding, you should not use Restylane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding or under 18, you should not use Restylane.

Restylane should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, or by people with previous bad allergies to drugs that have required in-hospital treatment. Restylane should not be injected anywhere except the skin or just under the skin.

The use of Restylane at the site of skin sores, pimples, rashes, hives, cysts or infection should be postponed until healing is complete. Use of Restylane in these instances could
delay healing or make your skin problems worse.

Important Safety Considerations of Perlane:
Perlane restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). After your treatment, you might have some swelling, redness, pain, bruising and tenderness. This will normally last less than seven days. Although rare, red or
swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising and bleeding, you should not use Perlane if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding or under 18, you should not use Perlane.

Perlane should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram positive bacteria, or by people with previous bad allergies to drugs that have required in-hospital treatment. Perlane should not be injected anywhere except the skin or just under the skin.

The use of Perlane at the site of skin sores, pimples, rashes, hives, cysts or infection should be postponed until healing is complete. Use of Perlane in these instances could delay healing or make your skin problems worse.